Compared with control group, IVC group had a significantly lower rate of type-B (20.9% vs. Groups were homogenous for age, sex, fracture severity, fracture location, fracture type, cement volume, puncture approach and property of cement. A general leakage rate and a specific leakage rate per each type were compared between both groups. Cement leakage were classified into four types, furtherly into two types. Non-IVC controls were matched in a 1:1 ratio in age (within 3 years), sex and fracture severity with patients in study group. After inclusive and exclusive criteria were met, a total of 139 patients with IVC were enrolled as the study group. Patients were eligible for this case-control study if they were diagnosed as single level fracture in spine. MethodsĪll patients with OVCFs who underwent PVP between January 2016 and June 2019 at our institution were retrospectively reviewed. The aim of the study was to evaluate the impact of IVC on the incidence of leakage through vein, leakage through cortex as well as general leakage in PVP for OVCFs. However, the results were conflicting, as the study population and cement leakage classification were heterogeneous. The impact of intravertebral cleft (IVC) on cement leakage in percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCFs) has been discussed.